Comparison
MGF (Mechano Growth Factor) vs. Sermorelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Growth
CAS no.
12-Aminosäuren-C-terminales E-Domänen-Peptid (Sequenz nicht standardisiert)
86168-78-7
Molecular weight
2867.2 g/mol
3358 g/mol
Half-life
0.1 h
0.2 h
Sequence
YQPPSTNKNTKSQRRKGSTFEERKYADAIFTNSYRKVLGQLSARKLLQDIMSRMechanism of action
MGF (Mechano Growth Factor)
The IGF-1 gene produces multiple isoforms by alternative splicing. IGF-1Ec is upregulated after mechanical muscle loading; the C-terminal E-domain is cleaved from the mature IGF-1 protein and appears to have independent effects on satellite cells. The exact receptor binding of the E-domain is not established; a classical IGF-1R effect is unlikely since mature IGF-1 is responsible. In cell-culture studies, stimulation of myoblast proliferation and differentiation has been observed.
Sermorelin
Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.
Evidence base
Highest evidence
Animal model
Human RCT
Studies
4
5
of which in humans
0
3
Effects recorded
3
3
Open conflicts
1
1
Documented adverse events
1
3
Legal status
Full entries
Frequently asked questions
- What is the difference between MGF (Mechano Growth Factor) and Sermorelin?
- MGF (Mechano Growth Factor) is classified as "Growth", while Sermorelin is classified as "Growth". MGF (Mechano Growth Factor): Synthetic peptide corresponding to the C-terminal E-domain of the IGF-1 splice variant IGF-1Ec. Described in preclinical studies as a 'mechano-induced' skeletal muscle repair factor. No marketing approval; clinical use largely confined to the black market. Sermorelin: Synthetic analogue of the first 29 amino acids of human GHRH. Stimulates pulsatile growth-hormone secretion from the pituitary. Formerly FDA-approved as Geref Diagnostic, now withdrawn in many markets — compounding and research use dominate. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, MGF (Mechano Growth Factor) or Sermorelin?
- The highest available evidence level is "Animal model" for MGF (Mechano Growth Factor) and "Human RCT" for Sermorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of MGF (Mechano Growth Factor) and Sermorelin in Germany and the United States?
- Germany: MGF (Mechano Growth Factor) — Unapproved, Sermorelin — Unapproved. United States: MGF (Mechano Growth Factor) — Unapproved, Sermorelin — Research only. These are factual summaries with source and review date on the individual pages.