Comparison
MGF (Mechano Growth Factor) vs. Sermorelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Growth
CAS no.
12-Aminosäuren-C-terminales E-Domänen-Peptid (Sequenz nicht standardisiert)
86168-78-7
Molecular weight
2867.2 g/mol
3358 g/mol
Half-life
0.1 h
0.2 h
Sequence
YQPPSTNKNTKSQRRKGSTFEERKYADAIFTNSYRKVLGQLSARKLLQDIMSRMechanism of action
MGF (Mechano Growth Factor)
The IGF-1 gene produces multiple isoforms by alternative splicing. IGF-1Ec is upregulated after mechanical muscle loading; the C-terminal E-domain is cleaved from the mature IGF-1 protein and appears to have independent effects on satellite cells. The exact receptor binding of the E-domain is not established; a classical IGF-1R effect is unlikely since mature IGF-1 is responsible. In cell-culture studies, stimulation of myoblast proliferation and differentiation has been observed.
Sermorelin
Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.
Evidence base
Highest evidence
Animal model
Human RCT
Studies
4
5
of which in humans
0
3
Effects recorded
3
3
Open conflicts
0
1
Documented adverse events
1
3