Comparison
Pasireotid vs. Sekretin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
396091-73-9
no data
Molecular weight
1047.21 g/mol
3055.5 g/mol
Half-life
no data
no data
Sequence
no data
no data
Mechanism of action
Pasireotid
Pasireotide binds more broadly than older somatostatin analogs (SSTR1/2/3/5) with particularly high affinity for SSTR5. This suppresses, among others, ACTH release in Cushing's disease and GH release in acromegaly.
Sekretin
Secretin binds the Gs-coupled secretin receptor (SCTR) on pancreatic duct cells, opens CFTR chloride channels and triggers secretion of bicarbonate-rich pancreatic fluid and bile flow.
Evidence base
Highest evidence
Human RCT
Human trial
Studies
1
0
of which in humans
1
0
Effects recorded
2
2
Open conflicts
0
0
Documented adverse events
2
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Pasireotid and Sekretin?
- Pasireotid is classified as "Research other", while Sekretin is classified as "Research other". Pasireotid: Pasireotide is a multireceptor somatostatin analog binding to four of the five somatostatin receptors (especially SSTR5). It is approved for Cushing's disease and acromegaly. Sekretin: Secretin is a 27-amino-acid hormone that regulates pancreatic bicarbonate secretion. As ChiRhoStim it is FDA-approved as a diagnostic agent (pancreatic function test, gastrinoma test, secretin-enhanced MRCP). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Pasireotid or Sekretin?
- The highest available evidence level is "Human RCT" for Pasireotid and "Human trial" for Sekretin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Pasireotid and Sekretin in Germany and the United States?
- Germany: Pasireotid — Prescription, Sekretin — Prescription. United States: Pasireotid — Prescription, Sekretin — Prescription. These are factual summaries with source and review date on the individual pages.