Comparison
Sekretin vs. Teduglutid
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
no data
197922-42-2
Molecular weight
3055.5 g/mol
3752.13 g/mol
Half-life
no data
no data
Sequence
no data
no data
Mechanism of action
Sekretin
Secretin binds the Gs-coupled secretin receptor (SCTR) on pancreatic duct cells, opens CFTR chloride channels and triggers secretion of bicarbonate-rich pancreatic fluid and bile flow.
Teduglutid
Teduglutide activates the GLP-2 receptor, promoting growth and regeneration of small-intestinal villi, increasing nutrient and fluid absorption and thereby reducing dependence on parenteral nutrition. The glycine substitution at position 2 makes it resistant to rapid breakdown by DPP-4.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
0
2
of which in humans
0
2
Effects recorded
2
2
Open conflicts
0
0
Documented adverse events
1
2
Legal status
Full entries
Frequently asked questions
- What is the difference between Sekretin and Teduglutid?
- Sekretin is classified as "Research other", while Teduglutid is classified as "Research other". Sekretin: Secretin is a 27-amino-acid hormone that regulates pancreatic bicarbonate secretion. As ChiRhoStim it is FDA-approved as a diagnostic agent (pancreatic function test, gastrinoma test, secretin-enhanced MRCP). Teduglutid: Teduglutide is a DPP-4-resistant analog of GLP-2 (glucagon-like peptide-2). It promotes growth and function of the intestinal mucosa and is approved for treating short bowel syndrome. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Sekretin or Teduglutid?
- The highest available evidence level is "Human trial" for Sekretin and "Human RCT" for Teduglutid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Sekretin and Teduglutid in Germany and the United States?
- Germany: Sekretin — Prescription, Teduglutid — Prescription. United States: Sekretin — Prescription, Teduglutid — Prescription. These are factual summaries with source and review date on the individual pages.