Comparison
Selank vs. Sermorelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Growth
CAS no.
129954-34-3
86168-78-7
Molecular weight
751.85 g/mol
3358 g/mol
Half-life
0.3 h
0.2 h
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-ProYADAIFTNSYRKVLGQLSARKLLQDIMSRMechanism of action
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Sermorelin
Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
5
of which in humans
2
3
Effects recorded
3
3
Open conflicts
0
1
Documented adverse events
1
3