Comparison
Selank vs. TB-500
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Healing
CAS no.
129954-34-3
no data
Molecular weight
751.85 g/mol
888 g/mol
Half-life
0.3 h
no data
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-ProAc-LKKTETQMechanism of action
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
TB-500
Synthetic fragment of the endogenous protein Thymosin Beta-4. In preclinical models, an influence on cell migration, actin sequestration and neovascularisation has been described. Robust human pharmacokinetic data are not publicly available.
Evidence base
Highest evidence
Human trial
Animal model
Studies
4
3
of which in humans
2
0
Effects recorded
3
4
Open conflicts
0
1
Documented adverse events
1
2