Comparison
Semax vs. Sermorelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Growth
CAS no.
80714-61-0
86168-78-7
Molecular weight
813.92 g/mol
3358 g/mol
Half-life
0.3 h
0.2 h
Sequence
Met-Glu-His-Phe-Pro-Gly-ProYADAIFTNSYRKVLGQLSARKLLQDIMSRMechanism of action
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Sermorelin
Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
5
of which in humans
2
3
Effects recorded
3
3
Open conflicts
0
1
Documented adverse events
1
3