Comparison
Semax vs. Thymalin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Healing
CAS no.
80714-61-0
63958-90-7
Molecular weight
813.92 g/mol
1000 g/mol
Half-life
0.3 h
0.5 h
Sequence
Met-Glu-His-Phe-Pro-Gly-Prono data
Mechanism of action
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Thymalin
Thymalin is a complex of multiple polypeptides extracted from bovine or calf thymus. Postulated mechanisms include modulation of T-lymphocyte maturation, influence on interleukin profiles and stimulation of cellular immune response. Being a multi-component preparation, individual mechanisms are difficult to disentangle. Khavinson and colleagues from St Petersburg have described the mechanism over decades in Russian publications.
Evidence base
Highest evidence
Human trial
Human trial
Studies
4
4
of which in humans
2
2
Effects recorded
3
3
Open conflicts
0
1
Documented adverse events
1
1