Comparison
TB-500 vs. Thymalin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Healing
Healing
CAS no.
no data
63958-90-7
Molecular weight
888 g/mol
1000 g/mol
Half-life
no data
0.5 h
Sequence
Ac-LKKTETQno data
Mechanism of action
TB-500
Synthetic fragment of the endogenous protein Thymosin Beta-4. In preclinical models, an influence on cell migration, actin sequestration and neovascularisation has been described. Robust human pharmacokinetic data are not publicly available.
Thymalin
Thymalin is a complex of multiple polypeptides extracted from bovine or calf thymus. Postulated mechanisms include modulation of T-lymphocyte maturation, influence on interleukin profiles and stimulation of cellular immune response. Being a multi-component preparation, individual mechanisms are difficult to disentangle. Khavinson and colleagues from St Petersburg have described the mechanism over decades in Russian publications.
Evidence base
Highest evidence
Animal model
Human trial
Studies
3
4
of which in humans
0
2
Effects recorded
4
3
Open conflicts
1
1
Documented adverse events
2
1