El glucagón es una hormona peptídica que eleva la glucosa en sangre; se usa para tratar la hipoglucemia grave (incluidas formas nasales).
Glucagon is produced in the alpha cells of the pancreas (islets of Langerhans) and released when blood sugar is low. Glucagon binds the glucagon receptor (GCGR), a G-protein-coupled receptor expressed predominantly on hepatocytes. Activation stimulates adenylate cyclase, raises cyclic AMP and activates protein kinase A. This drives glycogenolysis (breakdown of hepatic glycogen into glucose) and gluconeogenesis (de novo glucose synthesis), which raises blood glucose. Glucagon also promotes lipolysis. As the counterpart to insulin it contributes to glucose homeostasis. It transiently relaxes gastrointestinal smooth muscle, which is the basis of its diagnostic use in imaging.
Curva teórica de concentración con una semivida de 0.13 h. Modelo farmacocinético puro — no es una recomendación de dosis.
Open in PK tool →Baqsimi is indicated for the treatment of severe hypoglycaemia in patients with diabetes ages one year and older and is the first approved glucagon therapy that can be administered without an injection.
Los péptidos vienen como polvo seco. Una vez disuelto en un líquido (reconstitución), esta calculadora responde a una única pregunta: ¿cuánta sustancia hay en un mililitro de solución después?
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