Comparison
BPC-157 vs. Thymosin Alpha-1
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Healing
Healing
CAS no.
137525-51-0
62304-98-7
Molecular weight
1419.5 g/mol
3108.32 g/mol
Half-life
4 h
2 h
Sequence
GEPPPGKPADDAGLVAc-SDAAVDTSSEITTKDLKEKKEVVEEAENMechanism of action
BPC-157
Synthetic peptide derived from a sequence of a protein found in gastric juice. In preclinical models, an influence on angiogenic and tissue-protective signalling pathways has been described. The precise molecular mechanisms of action are not conclusively understood.
Thymosin Alpha-1
Thymosin Alpha-1 is an N-terminally acetylated peptide originally isolated from the thymus. It modulates T-lymphocyte maturation and function and acts on dendritic cells via Toll-like receptors (TLR9 / TLR2). In preclinical and some clinical studies, increased interferon-gamma responses and altered T-cell subpopulations have been reported.
Evidence base
Highest evidence
Animal model
Human RCT
Studies
5
4
of which in humans
0
4
Effects recorded
4
3
Open conflicts
2
1
Documented adverse events
2
1
Legal status
Full entries
Frequently asked questions
- What is the difference between BPC-157 and Thymosin Alpha-1?
- BPC-157 is classified as "Healing", while Thymosin Alpha-1 is classified as "Healing". BPC-157: Synthetic pentadecapeptide (15 amino acids) derived from a sequence of a gastric-juice protein. Studied predominantly in animal models on healing and protective processes — controlled human trials are rare and limited in scope. Thymosin Alpha-1: Synthetic 28-amino-acid peptide identical to a naturally occurring thymus peptide. Approved as Zadaxin in more than 30 countries (not US/EU) for hepatitis B treatment and as an immunomodulator. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, BPC-157 or Thymosin Alpha-1?
- The highest available evidence level is "Animal model" for BPC-157 and "Human RCT" for Thymosin Alpha-1. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of BPC-157 and Thymosin Alpha-1 in Germany and the United States?
- Germany: BPC-157 — Unapproved, Thymosin Alpha-1 — Unapproved. United States: BPC-157 — Research only, Thymosin Alpha-1 — Unapproved. These are factual summaries with source and review date on the individual pages.