Comparison
Carbetocin vs. Nafarelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
37025-55-1
no data
Molecular weight
no data
no data
Half-life
0.67 h
no data
Sequence
no data
no data
Mechanism of action
Carbetocin
Carbetocin is an oxytocin receptor agonist with prolonged duration. It triggers a sustained contraction of the uterus after birth, preventing atonic hemorrhage — unlike oxytocin, without a multi-hour infusion.
Nafarelin
Nafarelin is a potent GnRH agonist: after an initial stimulation ('flare'), continuous receptor occupancy leads to downregulation and thereby suppression of LH, FSH and the downstream sex hormones.
Evidence base
Highest evidence
Human RCT
Human RCT
Studies
1
0
of which in humans
1
0
Effects recorded
2
2
Open conflicts
0
0
Documented adverse events
1
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Carbetocin and Nafarelin?
- Carbetocin is classified as "Research other", while Nafarelin is classified as "Research other". Carbetocin: Carbetocin is a long-acting synthetic oxytocin analog (half-life ~40 minutes). It prevents postpartum hemorrhage as a single injection. Approved in Canada and the UK among others, NOT in the US. Nafarelin: Nafarelin is a GnRH agonist and the only member of this class delivered as a nasal spray. It is approved for treating endometriosis and central precocious puberty. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Carbetocin or Nafarelin?
- The highest available evidence level is "Human RCT" for Carbetocin and "Human RCT" for Nafarelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Carbetocin and Nafarelin in Germany and the United States?
- Germany: Carbetocin — Prescription, Nafarelin — Prescription. United States: Carbetocin — Unapproved, Nafarelin — Prescription. These are factual summaries with source and review date on the individual pages.