Comparison
Epitalon vs. Triptorelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
307297-39-8
57773-63-4
Molecular weight
390.35 g/mol
1311.45 g/mol
Half-life
0.3 h
3 h
Sequence
Ala-Glu-Asp-GlypGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2Mechanism of action
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
Triptorelin
Triptorelin binds with high affinity to the GnRH receptor in the pituitary. After initial stimulation of LH and FSH secretion (flare phase, about 1-2 weeks), receptor desensitisation follows with consecutive gonadotropin suppression. This results in a reversible chemical castration: in men testosterone, in women oestrogen suppression to the postmenopausal range.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
4
of which in humans
1
4
Effects recorded
4
3
Open conflicts
1
0
Documented adverse events
1
3
Legal status
Full entries
Frequently asked questions
- What is the difference between Epitalon and Triptorelin?
- Epitalon is classified as "Research other", while Triptorelin is classified as "Research other". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Triptorelin: Synthetic decapeptide GnRH agonist with increased affinity over native gonadotropin-releasing hormone. FDA- and EMA-approved since the 1980s for prostate cancer, endometriosis and precocious puberty. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Epitalon or Triptorelin?
- The highest available evidence level is "Human trial" for Epitalon and "Human RCT" for Triptorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Epitalon and Triptorelin in Germany and the United States?
- Germany: Epitalon — Unapproved, Triptorelin — Prescription. United States: Epitalon — Unapproved, Triptorelin — Prescription. These are factual summaries with source and review date on the individual pages.