Comparison
GHK-Cu vs. Hexarelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Cosmetic
Growth
CAS no.
49557-75-7
140703-51-1
Molecular weight
340.4 g/mol
887.05 g/mol
Half-life
no data
0.9 h
Sequence
GHKHis-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2Mechanism of action
GHK-Cu
Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. In skin-cell models and skin biopsies an influence on collagen synthesis, antioxidant markers, gene-expression profiles and wound-healing processes has been described. In topical use in cosmetic studies, changes in various skin parameters have been reported.
Hexarelin
Hexarelin is a synthetic analog of the GHRP-6 family binding both the GH secretagogue receptor (GHSR-1a) and CD36. GHSR activation in the pituitary releases pulsatile growth hormone. Via CD36 in endothelium and myocardium, cardioprotective effects have been described in animal studies.
Evidence base
Highest evidence
Human trial
Human trial
Studies
3
4
of which in humans
1
3
Effects recorded
4
3
Open conflicts
1
0
Documented adverse events
2
1