Comparison
Hexarelin vs. Selank
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Research other
CAS no.
140703-51-1
129954-34-3
Molecular weight
887.05 g/mol
751.85 g/mol
Half-life
0.9 h
0.3 h
Sequence
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2Thr-Lys-Pro-Arg-Pro-Gly-ProMechanism of action
Hexarelin
Hexarelin is a synthetic analog of the GHRP-6 family binding both the GH secretagogue receptor (GHSR-1a) and CD36. GHSR activation in the pituitary releases pulsatile growth hormone. Via CD36 in endothelium and myocardium, cardioprotective effects have been described in animal studies.
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Evidence base
Highest evidence
Human trial
Human trial
Studies
4
4
of which in humans
3
2
Effects recorded
3
3
Open conflicts
0
0
Documented adverse events
1
1