Comparison
Hexarelin vs. Semax
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Research other
CAS no.
140703-51-1
80714-61-0
Molecular weight
887.05 g/mol
813.92 g/mol
Half-life
0.9 h
0.3 h
Sequence
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2Met-Glu-His-Phe-Pro-Gly-ProMechanism of action
Hexarelin
Hexarelin is a synthetic analog of the GHRP-6 family binding both the GH secretagogue receptor (GHSR-1a) and CD36. GHSR activation in the pituitary releases pulsatile growth hormone. Via CD36 in endothelium and myocardium, cardioprotective effects have been described in animal studies.
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Evidence base
Highest evidence
Human trial
Human trial
Studies
4
4
of which in humans
3
2
Effects recorded
3
3
Open conflicts
0
0
Documented adverse events
1
1