Comparison
Plecanatid vs. Sekretin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
467426-54-6
no data
Molecular weight
1682 g/mol
3055.5 g/mol
Half-life
no data
no data
Sequence
no data
no data
Mechanism of action
Plecanatid
Plecanatide is structurally analogous to the body's own uroguanylin and, like it, activates the GC-C receptor at the gut surface, raising cGMP and fluid secretion. Its pH-dependent activity shifts the effect toward the proximal small intestine.
Sekretin
Secretin binds the Gs-coupled secretin receptor (SCTR) on pancreatic duct cells, opens CFTR chloride channels and triggers secretion of bicarbonate-rich pancreatic fluid and bile flow.
Evidence base
Highest evidence
Human RCT
Human trial
Studies
0
0
of which in humans
0
0
Effects recorded
2
2
Open conflicts
1
0
Documented adverse events
1
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Plecanatid and Sekretin?
- Plecanatid is classified as "Research other", while Sekretin is classified as "Research other". Plecanatid: Plecanatide is a 16-amino-acid analog of the body's own uroguanylin and a guanylate cyclase-C (GC-C) agonist. It is approved for chronic idiopathic constipation (CIC) and IBS with constipation (IBS-C). Sekretin: Secretin is a 27-amino-acid hormone that regulates pancreatic bicarbonate secretion. As ChiRhoStim it is FDA-approved as a diagnostic agent (pancreatic function test, gastrinoma test, secretin-enhanced MRCP). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Plecanatid or Sekretin?
- The highest available evidence level is "Human RCT" for Plecanatid and "Human trial" for Sekretin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Plecanatid and Sekretin in Germany and the United States?
- Germany: Plecanatid — Unapproved, Sekretin — Prescription. United States: Plecanatid — Prescription, Sekretin — Prescription. These are factual summaries with source and review date on the individual pages.