Comparison
Plecanatid vs. Sincalide
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
467426-54-6
25126-32-3
Molecular weight
1682 g/mol
1143.29 g/mol
Half-life
no data
no data
Sequence
no data
Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2Mechanism of action
Plecanatid
Plecanatide is structurally analogous to the body's own uroguanylin and, like it, activates the GC-C receptor at the gut surface, raising cGMP and fluid secretion. Its pH-dependent activity shifts the effect toward the proximal small intestine.
Sincalide
Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).
Evidence base
Highest evidence
Human RCT
Human trial
Studies
0
0
of which in humans
0
0
Effects recorded
2
1
Open conflicts
1
0
Documented adverse events
1
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Plecanatid and Sincalide?
- Plecanatid is classified as "Research other", while Sincalide is classified as "Research other". Plecanatid: Plecanatide is a 16-amino-acid analog of the body's own uroguanylin and a guanylate cyclase-C (GC-C) agonist. It is approved for chronic idiopathic constipation (CIC) and IBS with constipation (IBS-C). Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Plecanatid or Sincalide?
- The highest available evidence level is "Human RCT" for Plecanatid and "Human trial" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Plecanatid and Sincalide in Germany and the United States?
- Germany: Plecanatid — Unapproved, Sincalide — Unclear. United States: Plecanatid — Prescription, Sincalide — Prescription. These are factual summaries with source and review date on the individual pages.