Comparison
Sekretin vs. Sincalide
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
no data
25126-32-3
Molecular weight
3055.5 g/mol
1143.29 g/mol
Half-life
no data
no data
Sequence
no data
Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2Mechanism of action
Sekretin
Secretin binds the Gs-coupled secretin receptor (SCTR) on pancreatic duct cells, opens CFTR chloride channels and triggers secretion of bicarbonate-rich pancreatic fluid and bile flow.
Sincalide
Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).
Evidence base
Highest evidence
Human trial
Human trial
Studies
0
0
of which in humans
0
0
Effects recorded
2
1
Open conflicts
0
0
Documented adverse events
1
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Sekretin and Sincalide?
- Sekretin is classified as "Research other", while Sincalide is classified as "Research other". Sekretin: Secretin is a 27-amino-acid hormone that regulates pancreatic bicarbonate secretion. As ChiRhoStim it is FDA-approved as a diagnostic agent (pancreatic function test, gastrinoma test, secretin-enhanced MRCP). Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Sekretin or Sincalide?
- The highest available evidence level is "Human trial" for Sekretin and "Human trial" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Sekretin and Sincalide in Germany and the United States?
- Germany: Sekretin — Prescription, Sincalide — Unclear. United States: Sekretin — Prescription, Sincalide — Prescription. These are factual summaries with source and review date on the individual pages.