Comparison
Epitalon vs. Selank
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
307297-39-8
129954-34-3
Molecular weight
390.35 g/mol
751.85 g/mol
Half-life
0.3 h
0.3 h
Sequence
Ala-Glu-Asp-GlyThr-Lys-Pro-Arg-Pro-Gly-ProMechanism of action
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Evidence base
Highest evidence
Human trial
Human trial
Studies
4
4
of which in humans
1
2
Effects recorded
4
3
Open conflicts
1
0
Documented adverse events
1
1