Comparison
Icatibant vs. Selank
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
138614-30-9
129954-34-3
Molecular weight
1304.52 g/mol
751.85 g/mol
Half-life
no data
0.3 h
Sequence
no data
Thr-Lys-Pro-Arg-Pro-Gly-ProMechanism of action
Icatibant
Icatibant competitively blocks the bradykinin B2 receptor. Because bradykinin mediates the vascular permeability, swelling and pain typical of hereditary angioedema, the blockade interrupts the acute attack.
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Evidence base
Highest evidence
Human RCT
Human trial
Studies
1
4
of which in humans
1
2
Effects recorded
1
3
Open conflicts
0
1
Documented adverse events
1
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Icatibant and Selank?
- Icatibant is classified as "Research other", while Selank is classified as "Research other". Icatibant: Icatibant is a synthetic decapeptide and selective antagonist of the bradykinin B2 receptor. It is approved to treat acute attacks of hereditary angioedema (HAE). Selank: Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Icatibant or Selank?
- The highest available evidence level is "Human RCT" for Icatibant and "Human trial" for Selank. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Icatibant and Selank in Germany and the United States?
- Germany: Icatibant — Prescription, Selank — Unapproved. United States: Icatibant — Prescription, Selank — Unapproved. These are factual summaries with source and review date on the individual pages.