Comparison
Semax vs. Vasopressin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
80714-61-0
no data
Molecular weight
813.92 g/mol
1084.23 g/mol
Half-life
0.3 h
no data
Sequence
Met-Glu-His-Phe-Pro-Gly-Prono data
Mechanism of action
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Vasopressin
Vasopressin binds V1 receptors (vasoconstriction, raising vascular resistance) and V2 receptors (renal water reabsorption via aquaporin channels). This raises blood pressure and acts antidiuretically. Desmopressin is the V2-selective synthetic analog.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
0
of which in humans
2
0
Effects recorded
3
2
Open conflicts
1
0
Documented adverse events
1
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Semax and Vasopressin?
- Semax is classified as "Research other", while Vasopressin is classified as "Research other". Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. Vasopressin: Vasopressin (arginine vasopressin, antidiuretic hormone/ADH) is a cyclic nonapeptide hormone that regulates water balance and vascular tone. As Vasostrict it is approved to raise blood pressure in vasodilatory shock. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Semax or Vasopressin?
- The highest available evidence level is "Human trial" for Semax and "Human RCT" for Vasopressin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Semax and Vasopressin in Germany and the United States?
- Germany: Semax — Unapproved, Vasopressin — Prescription. United States: Semax — Unapproved, Vasopressin — Prescription. These are factual summaries with source and review date on the individual pages.