Family
Metabolic
Peptides related to metabolism, glucose regulation or body weight.
Family covering metabolic modulation — structures derived from endogenous hormones or analogues thereof. Mechanisms of action are in part well described, but cross-species transfer varies considerably.
This overview is editorial. It describes the evidence base, not a usage recommendation.
Members
9 entries in this familyCagrilintide
Human RCT4 studies · 3 observations
Cagrilintide binds amylin receptors (AMY1, AMY3, formed by the calcitonin receptor plus RAMP proteins). Activation delays gastric emptying, inhibits postprandia…
Dulaglutide
Human RCT5 studies · 3 observations
Dulaglutide consists of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc. The Fc fusion increases molecular weight substantially (~60 kDa…
Exenatide
Human RCT5 studies · 3 observations
Exenatide is a 39-amino-acid peptide with about 53% sequence homology to human GLP-1. A glycine substitution at position 2 prevents dipeptidyl-peptidase-IV clea…
Liraglutide
Human RCT5 studies · 3 observations
Liraglutide is a synthetic GLP-1 analog with 97% sequence identity to human GLP-1. A fatty-acid side chain (C16) on Lys-26 reversibly binds serum albumin and pr…
Lixisenatide
Human RCT5 studies · 3 observations
Lixisenatide is a 44-amino-acid peptide based on exendin-4 (see exenatide) with six additional lysine residues at the C-terminus. This modification increases st…
Retatrutide
Human RCT5 studies · 4 observations
Retatrutide is a 39-amino-acid peptide with agonism at three incretin/energy-balance receptors: GLP-1R (insulin secretion, satiety), GIPR (insulin sensitivity, …
Semaglutid
Human RCT4 studies · 3 observations
Long-acting agonist at the GLP-1 receptor. Structurally a modified glucagon-like peptide 1 whose long half-life is achieved via a fatty-acid side chain and reve…
Survodutide
Human RCT2 studies · 3 observations
Survodutide is a dual agonist at the GLP-1 and glucagon receptors. The GLP-1 component mediates glucose-dependent insulin secretion, inhibition of glucagon secr…
Tirzepatide
Human RCT3 studies · 4 observations
Tirzepatide is a 39-amino-acid peptide acting as a dual agonist at the GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) re…