La afamelanotida es un análogo de la α-MSH (Scenesse), aprobado para prevenir la fototoxicidad en la protoporfiria eritropoyética.
Afamelanotide is a synthetic analogue of α-melanocyte-stimulating hormone. It differs from native α-MSH by two substitutions — norleucine at position 4 and D-phenylalanine at position 7 — which make it metabolically more stable and more potent. As an agonist at the melanocortin-1 receptor (MC1R) on melanocytes, it activates adenylate cyclase, raises cAMP and increases tyrosinase activity via the transcription factor MITF. This shifts pigment synthesis toward eumelanin, which absorbs UV and visible light and has antioxidant properties — the presumed mechanism of photoprotection in EPP.
Curva teórica de concentración con una semivida de 12 h. Modelo farmacocinético puro — no es una recomendación de dosis.
Open in PK tool →Scenesse is the first FDA-approved therapy to increase pain-free light exposure in adults with a history of phototoxic reactions from erythropoietic protoporphyria.
Los péptidos vienen como polvo seco. Una vez disuelto en un líquido (reconstitución), esta calculadora responde a una única pregunta: ¿cuánta sustancia hay en un mililitro de solución después?
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