Comparison
Hexarelin vs. Sermorelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Growth
CAS no.
140703-51-1
86168-78-7
Molecular weight
887.05 g/mol
3358 g/mol
Half-life
0.9 h
0.2 h
Sequence
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2YADAIFTNSYRKVLGQLSARKLLQDIMSRMechanism of action
Hexarelin
Hexarelin is a synthetic analog of the GHRP-6 family binding both the GH secretagogue receptor (GHSR-1a) and CD36. GHSR activation in the pituitary releases pulsatile growth hormone. Via CD36 in endothelium and myocardium, cardioprotective effects have been described in animal studies.
Sermorelin
Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
5
of which in humans
3
3
Effects recorded
3
3
Open conflicts
0
1
Documented adverse events
1
3