Comparison
Hexarelin vs. Sermorelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Growth
CAS no.
140703-51-1
86168-78-7
Molecular weight
887.05 g/mol
3358 g/mol
Half-life
0.9 h
0.2 h
Sequence
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2YADAIFTNSYRKVLGQLSARKLLQDIMSRMechanism of action
Hexarelin
Hexarelin is a synthetic analog of the GHRP-6 family binding both the GH secretagogue receptor (GHSR-1a) and CD36. GHSR activation in the pituitary releases pulsatile growth hormone. Via CD36 in endothelium and myocardium, cardioprotective effects have been described in animal studies.
Sermorelin
Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
5
of which in humans
3
3
Effects recorded
3
3
Open conflicts
0
1
Documented adverse events
1
3
Legal status
Full entries
Frequently asked questions
- What is the difference between Hexarelin and Sermorelin?
- Hexarelin is classified as "Growth", while Sermorelin is classified as "Growth". Hexarelin: Synthetic hexapeptide of the growth-hormone secretagogue (GHRP) family. In the 1990s investigated as an acromegaly diagnostic and for GH deficiency. Not an approved medicine. Sermorelin: Synthetic analogue of the first 29 amino acids of human GHRH. Stimulates pulsatile growth-hormone secretion from the pituitary. Formerly FDA-approved as Geref Diagnostic, now withdrawn in many markets — compounding and research use dominate. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Hexarelin or Sermorelin?
- The highest available evidence level is "Human trial" for Hexarelin and "Human RCT" for Sermorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Hexarelin and Sermorelin in Germany and the United States?
- Germany: Hexarelin — Unapproved, Sermorelin — Unapproved. United States: Hexarelin — Unapproved, Sermorelin — Research only. These are factual summaries with source and review date on the individual pages.