Comparison
Semax vs. Triptorelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
80714-61-0
57773-63-4
Molecular weight
813.92 g/mol
1311.45 g/mol
Half-life
0.3 h
3 h
Sequence
Met-Glu-His-Phe-Pro-Gly-PropGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2Mechanism of action
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Triptorelin
Triptorelin binds with high affinity to the GnRH receptor in the pituitary. After initial stimulation of LH and FSH secretion (flare phase, about 1-2 weeks), receptor desensitisation follows with consecutive gonadotropin suppression. This results in a reversible chemical castration: in men testosterone, in women oestrogen suppression to the postmenopausal range.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
4
of which in humans
2
4
Effects recorded
3
3
Open conflicts
1
0
Documented adverse events
1
3
Legal status
Full entries
Frequently asked questions
- What is the difference between Semax and Triptorelin?
- Semax is classified as "Research other", while Triptorelin is classified as "Research other". Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. Triptorelin: Synthetic decapeptide GnRH agonist with increased affinity over native gonadotropin-releasing hormone. FDA- and EMA-approved since the 1980s for prostate cancer, endometriosis and precocious puberty. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Semax or Triptorelin?
- The highest available evidence level is "Human trial" for Semax and "Human RCT" for Triptorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Semax and Triptorelin in Germany and the United States?
- Germany: Semax — Unapproved, Triptorelin — Prescription. United States: Semax — Unapproved, Triptorelin — Prescription. These are factual summaries with source and review date on the individual pages.