Comparison
TB-500 vs. Thymosin Alpha-1
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Healing
Healing
CAS no.
no data
62304-98-7
Molecular weight
888 g/mol
3108.32 g/mol
Half-life
no data
2 h
Sequence
Ac-LKKTETQAc-SDAAVDTSSEITTKDLKEKKEVVEEAENMechanism of action
TB-500
Synthetic fragment of the endogenous protein Thymosin Beta-4. In preclinical models, an influence on cell migration, actin sequestration and neovascularisation has been described. Robust human pharmacokinetic data are not publicly available.
Thymosin Alpha-1
Thymosin Alpha-1 is an N-terminally acetylated peptide originally isolated from the thymus. It modulates T-lymphocyte maturation and function and acts on dendritic cells via Toll-like receptors (TLR9 / TLR2). In preclinical and some clinical studies, increased interferon-gamma responses and altered T-cell subpopulations have been reported.
Evidence base
Highest evidence
Animal model
Human RCT
Studies
3
2
of which in humans
0
2
Effects recorded
4
3
Open conflicts
1
1
Documented adverse events
2
1