Comparison
TB-500 vs. Thymosin Alpha-1
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Healing
Healing
CAS no.
no data
62304-98-7
Molecular weight
888 g/mol
3108.32 g/mol
Half-life
no data
2 h
Sequence
Ac-LKKTETQAc-SDAAVDTSSEITTKDLKEKKEVVEEAENMechanism of action
TB-500
Synthetic fragment of the endogenous protein Thymosin Beta-4. In preclinical models, an influence on cell migration, actin sequestration and neovascularisation has been described. Robust human pharmacokinetic data are not publicly available.
Thymosin Alpha-1
Thymosin Alpha-1 is an N-terminally acetylated peptide originally isolated from the thymus. It modulates T-lymphocyte maturation and function and acts on dendritic cells via Toll-like receptors (TLR9 / TLR2). In preclinical and some clinical studies, increased interferon-gamma responses and altered T-cell subpopulations have been reported.
Evidence base
Highest evidence
Animal model
Human RCT
Studies
3
4
of which in humans
0
4
Effects recorded
4
3
Open conflicts
1
1
Documented adverse events
2
1
Legal status
Full entries
Frequently asked questions
- What is the difference between TB-500 and Thymosin Alpha-1?
- TB-500 is classified as "Healing", while Thymosin Alpha-1 is classified as "Healing". TB-500: Synthetic fragment of the endogenous protein Thymosin Beta-4, specifically the actin-binding sequence. Preclinical models investigate effects on cell migration, neovascularisation and wound healing — robust human data are absent. Thymosin Alpha-1: Synthetic 28-amino-acid peptide identical to a naturally occurring thymus peptide. Approved as Zadaxin in more than 30 countries (not US/EU) for hepatitis B treatment and as an immunomodulator. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, TB-500 or Thymosin Alpha-1?
- The highest available evidence level is "Animal model" for TB-500 and "Human RCT" for Thymosin Alpha-1. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of TB-500 and Thymosin Alpha-1 in Germany and the United States?
- Germany: TB-500 — Unapproved, Thymosin Alpha-1 — Unapproved. United States: TB-500 — Research only, Thymosin Alpha-1 — Unapproved. These are factual summaries with source and review date on the individual pages.