Comparison
Hexarelin vs. MGF (Mechano Growth Factor)
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Growth
Growth
CAS no.
140703-51-1
12-Aminosäuren-C-terminales E-Domänen-Peptid (Sequenz nicht standardisiert)
Molecular weight
887.05 g/mol
2867.2 g/mol
Half-life
0.9 h
0.1 h
Sequence
His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2YQPPSTNKNTKSQRRKGSTFEERKMechanism of action
Hexarelin
Hexarelin is a synthetic analog of the GHRP-6 family binding both the GH secretagogue receptor (GHSR-1a) and CD36. GHSR activation in the pituitary releases pulsatile growth hormone. Via CD36 in endothelium and myocardium, cardioprotective effects have been described in animal studies.
MGF (Mechano Growth Factor)
The IGF-1 gene produces multiple isoforms by alternative splicing. IGF-1Ec is upregulated after mechanical muscle loading; the C-terminal E-domain is cleaved from the mature IGF-1 protein and appears to have independent effects on satellite cells. The exact receptor binding of the E-domain is not established; a classical IGF-1R effect is unlikely since mature IGF-1 is responsible. In cell-culture studies, stimulation of myoblast proliferation and differentiation has been observed.
Evidence base
Highest evidence
Human trial
Animal model
Studies
4
4
of which in humans
3
0
Effects recorded
3
3
Open conflicts
0
1
Documented adverse events
1
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Hexarelin and MGF (Mechano Growth Factor)?
- Hexarelin is classified as "Growth", while MGF (Mechano Growth Factor) is classified as "Growth". Hexarelin: Synthetic hexapeptide of the growth-hormone secretagogue (GHRP) family. In the 1990s investigated as an acromegaly diagnostic and for GH deficiency. Not an approved medicine. MGF (Mechano Growth Factor): Synthetic peptide corresponding to the C-terminal E-domain of the IGF-1 splice variant IGF-1Ec. Described in preclinical studies as a 'mechano-induced' skeletal muscle repair factor. No marketing approval; clinical use largely confined to the black market. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Hexarelin or MGF (Mechano Growth Factor)?
- The highest available evidence level is "Human trial" for Hexarelin and "Animal model" for MGF (Mechano Growth Factor). A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Hexarelin and MGF (Mechano Growth Factor) in Germany and the United States?
- Germany: Hexarelin — Unapproved, MGF (Mechano Growth Factor) — Unapproved. United States: Hexarelin — Unapproved, MGF (Mechano Growth Factor) — Unapproved. These are factual summaries with source and review date on the individual pages.