Comparison
Selank vs. Semax
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
129954-34-3
80714-61-0
Molecular weight
751.85 g/mol
813.92 g/mol
Half-life
0.3 h
0.3 h
Sequence
Thr-Lys-Pro-Arg-Pro-Gly-ProMet-Glu-His-Phe-Pro-Gly-ProMechanism of action
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Evidence base
Highest evidence
Human trial
Human trial
Studies
4
4
of which in humans
2
2
Effects recorded
3
3
Open conflicts
0
0
Documented adverse events
1
1